p21

Gene basic information

symbol APTR
name Alu-mediated CDKN1A/p21 transcriptional regulator (non-protein coding)
location 7q11.23
alias_symbol
alias_name
Tissuebone marrow,colorectum,liver,lung,nervous system,others,
Cancercolorectal cancer,diffuse large B cell lymphoma,glioma,hepatic cancer,lung cancer,lymphoma,sarcoma,


Description

LncRNA p21 is lower in diffuse large B cell lymphoma (1), glioma (2), lung cancer, sarcoma, lymphoma (3), colorectal cancer (4) and hepatic carcinoma (5). Its expression level is associated with prognosis (4, 5). It can regulate cancer cell proliferation and apoptosis.


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 p21 lung lung cancer / TS p53 pathway hnRNP-K,+p53 Noxa+,Perp+,Bcl2l3+,Stat3+,Atf2+ + 20673990
1 p21 bone marrow lymphoma / TS p53 pathway hnRNP-K,+p53 Noxa+,Perp+,Bcl2l3+,Stat3+,Atf2+ + 20673990
2 p21 others sarcoma / TS p53 pathway hnRNP-K,+p53 Noxa+,Perp+,Bcl2l3+,Stat3+,Atf2+ + 20673990
3 p21 colorectum colorectal cancer down TS 24012455
4 p21 colorectum colorectal cancer down / β-catenin+ + radiation resistance 24573322
5 p21 liver hepatic cancer down TS p53 - + + drug resistance,hormonal resistance 26305675
6 p21 bone marrow diffuse large B cell lymphoma down TS cyclin D1-,CDK4-,p21+ - + chemotherapy resistance 26475621
7 p21 colorectum colorectal cancer down TS β-catenin signaling miR-451 cancer stem cells 26497997
8 p21 nervous system glioma down / Wnt/β-catenin signal activity- β-catenin-,-HuR,-miR-146b-5p 27166258

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 6 7 fpkm 1.0 2.0 3.0 2.0 3.0 0.9 3.0 1.0 2.0 3.0 2.0 3.0 5.0 0.2 3.0 7.0 p21

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 5 fpkm p21 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Peng W, Wu J, Feng J (2017). LincRNA-p21 predicts favorable clinical outcome and impairs tumorigenesis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy. Clin Exp Med 17(1): 1-8. link pubmed
[2]. Yang W, Yu H, Shen Y, Liu Y, Yang Z, et al. (2016). MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway. Oncotarget 7(27): 41505-41526. link pubmed
[3]. Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, et al. (2010). A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 142(3): 409-19. link pubmed
[4]. Zhai H, Fesler A, Schee K, Fodstad O, Flatmark K, et al. (2013). Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer. Clin Colorectal Cancer 12(4): 261-6. link pubmed
[5]. Yang N, Fu Y, Zhang H, Sima H, Zhu N, et al. (2015). LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma. Oncotarget 6(29): 28151-63. link pubmed



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