P2RX7-V3

Gene basic information

symbol P2RX7
name purinergic receptor P2X 7
location 12q24.31
alias_symbol P2X7|MGC20089
alias_name
Tissueothers,
Canceruveal melanoma,


Description

LncRNA P2RX7-V3 (P2RX7 variant 3) is a transcriptional variant transcribed from the P2RX7 gene locus, which is expressed at a high level in uveal melanoma (UM) cells. P2RX7-V3 silencing reveals that this variant acts as a necessary UM oncoRNA. Knockdown of P2RX7-V3 expression significantly suppresses tumor growth and cancer cell migration. Moreover, knockdown of P2RX7-V3 leads to decreased vimentin and increased E-cadherin. Besides, a genome-wide cDNA array reveals that a variety of genes are dysregulated following P2RX7-V3 silencing (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 P2RX7-V3 others uveal melanoma up onco PI3K-AKT vimentin+,E-cadherin- + + + mutation 27468714

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 fpkm 1.0 2.0 9.0 1.0 1.0 0.4 0.4 8.0 0.5 2.0 4.0 3.0 3.0 0.1 2.0 0.6 P2RX7-V3

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Pan H, Ni H, Zhang L, Xing Y, Fan J, et al. (2016). P2RX7-V3 is a novel oncogene that promotes tumorigenesis in uveal melanoma. Tumour Biol 37(10): 13533-13543. link pubmed



© Bioinformatics Group of XTBG