PANDAR

Gene basic information

symbol PANDAR
name promoter of CDKN1A antisense DNA damage activated RNA
location 6p21.2
alias_symbol PANDA
alias_name p21 associated ncRNA DNA damage activated
Tissuebladder,breast,liver,lung,stomach,
Cancerbladder cancer,breast cancer,gastric cancer,hepatic cancer,non-small-cell lung cancer,


Description

LncRNA PANDAR is higher in breast cancer (1), gastric cancer (2), hepatocellular carcinoma (3) and bladder cancer (4), and lower in lung cancer (5). PANDAR expression level is associated with clinicopathological parameters such as depth of invasion lymphatic metastasis, histological grade, TNM stage and prognosis etc. (4, 2, 3, 5, 5). Functionally, PANDAR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT (4). Mechanistically, PANDAR negatively regulates p16 (1) and Bcl-2 (5).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PANDAR lung non-small-cell lung cancer down TS Bcl-2-,+p53 - + 25719249
1 PANDAR liver hepatic cancer up onco + - biomarker 26054684
2 PANDAR stomach gastric cancer up onco - 26898439
3 PANDAR breast breast cancer up onco p16- + 26927017
4 PANDAR bladder bladder cancer up onco + - + 27206339

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.02 0.04 0.06 0.08 0.10 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 PANDAR

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Sang Y, Tang J, Li S, Li L, Tang X, et al. (2016). LncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16(INK4A) expression. Sci Rep 6: 22366. link pubmed
[2]. Ma P, Xu T, Huang M, Shu Y (2016). Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer. Biomed Pharmacother 78: 172-6. link pubmed
[3]. Peng W, Fan H (2015). Long non-coding RNA PANDAR correlates with poor prognosis and promotes tumorigenesis in hepatocellular carcinoma. Biomed Pharmacother 72: 113-8. link pubmed
[4]. Zhan Y, Lin J, Liu Y, Chen M, Chen X, et al. (2016). Up-regulation of long non-coding RNA PANDAR is associated with poor prognosis and promotes tumorigenesis in bladder cancer. J Exp Clin Cancer Res 35(1): 83. link pubmed
[5]. Han L, Zhang EB, Yin DD, Kong R, Xu TP, et al. (2015). Low expression of long noncoding RNA PANDAR predicts a poor prognosis of non-small cell lung cancer and affects cell apoptosis by regulating Bcl-2. Cell Death Dis 6: e1665. link pubmed



© Bioinformatics Group of XTBG