PAUPAR

Gene basic information

symbol PAUPAR
name PAX6 upstream antisense RNA
location 11p13
alias_symbol
alias_name
Tissueothers,
Canceruveal melanoma,


Description

LncRNA PAUPAR is down regulated in uveal melanoma (UM). Further studies reveal that PAUPAR acts as a necessary UM suppressor and induces the silencing of HES1 expression, which significantly reduces tumor metastasis. Mechanistically, PAUPAR modulates HES1 expression by inhibiting histone H3K4 methylation (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PAUPAR others uveal melanoma down TS HES1- - 27214741

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.02 0.04 0.06 0.08 0.10 fpkm 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PAUPAR

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Ding X, Wang X, Lin M, Xing Y, Ge S, et al. (2016). PAUPAR lncRNA suppresses tumourigenesis by H3K4 demethylation in uveal melanoma. FEBS Lett 590(12): 1729-38. link pubmed



© Bioinformatics Group of XTBG