PAX8-AS1

Gene basic information

symbol PAX8-AS1
name PAX8 antisense RNA 1
location 2q14.1
alias_symbol
alias_name
Tissuecervix,
Cancercervical cancer,


Description

LncRNA PAX8-AS1, a potential regulator of PAX8, contains specific single nucleotide polymorphisms (SNPs) that may represent expression quantitative trait loci (eQTLs) for PAX8. The study is conducted to identify the associations between two eQTLs SNPs (rs4848320 and rs1110839) and cervical cancer. The results reveal that variant allele T of rs4848320 and G of rs1110839 are associated with decreased risk of cervical cancer. Moreover, the haplotype containing variant alleles of the two SNPs significantly decreases the risk of cervical cancer compared to the most frequent haplotype (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PAX8-AS1 cervix cervical cancer / / PAX8 SNP 27225188

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.5 1.0 1.0 0.1 0.0 0.7 0.8 0.5 0.3 2.0 1.0 0.5 1.0 0.1 1.0 1.0 PAX8-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm PAX8-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Han J, Zhou W, Jia M, Wen J, Jiang J, et al. (2016). Expression quantitative trait loci in long non-coding RNA PAX8-AS1 are associated with decreased risk of cervical cancer. Mol Genet Genomics 291(4): 1743-8. link pubmed



© Bioinformatics Group of XTBG