PCA3

Gene basic information

symbol PCA3
name prostate cancer associated 3 (non-protein coding)
location 9q21.2
alias_symbol DD3|NCRNA00019|PCAT3
alias_name non-protein coding RNA 19|prostate cancer associated transcript 3 (non-protein coding)
Tissueprostate,
Cancerprostate cancer,


Description

LncRNA PCA3 is an antisense intronic lncRNA within a single PRUNE2 transcriptional unit. Levels of lncRNA PCA3 and PRUNE2 are inversely correlated in human prostate cancer specimens. Further studies reveal that PCA3 binds PRUNE2 pre-mRNA and regulates its expression. In addition, PCA3 functions as an oncogene in prostate cancer (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PCA3 prostate prostate cancer up onco PRUNE2- + 26080435
1 PCA3 prostate prostate cancer / / hormonal resistance 26960690

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 fpkm 0.1 0.1 0.5 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.1 9.0 0.0 0.1 0.1 PCA3

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 10 20 30 40 50 60 70 80 fpkm PCA3 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Salameh A, Lee AK, Cardó-Vila M, Nunes DN, Efstathiou E, et al. (2015). PRUNE2 is a human prostate cancer suppressor regulated by the intronic long noncoding RNA PCA3. Proc Natl Acad Sci U S A 112(27): 8403-8. link pubmed



© Bioinformatics Group of XTBG