PCAT1

Gene basic information

symbol PCAT1
name prostate cancer associated transcript 1 (non-protein coding)
location 8q24.21
alias_symbol PCAT-1|PCA1
alias_name
Tissuebladder,colorectum,esophagus,liver,lung,prostate,
Cancerbladder cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,non-small-cell lung cancer,prostate cancer,


Description

LncRNA PCAT1 is higher in bladder cancer (1), esophageal squamous carcinoma (2) colorectal cancer (3), hepatocellular carcinoma (4), lung cancer (5) and prostate cancer (6). PCAT1 expression level is associated with clinicopathological parameters such as TNM stage, depth of tumor invasion, lymph node metastasis, prognosis etc. (2, 7). Moreover, PCAT1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (4, 5). Besides, PCAT1 negatively regulates caspase-3 (4).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PCAT1 colorectum colorectal cancer up / - biomarker 23640607
1 PCAT1 prostate prostate cancer up onco cMyc+,-miR-3667-3p + - 25425964
2 PCAT1 esophagus esophageal squamous cell cancer up onco - 25731728
3 PCAT1 bladder bladder cancer up onco + - 25934337
4 PCAT1 liver hepatic cancer up / - 26097602
5 PCAT1 lung non-small-cell lung cancer up onco + + + 26770456
6 PCAT1 liver hepatic cancer up onco caspase-3- + - + 27035680
7 PCAT1 prostate prostate cancer / / ONECUT2 AR,LSD1 + SNP 27526323

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 fpkm 0.1 0.6 0.1 0.2 0.1 0.1 0.4 0.1 0.1 0.2 0.2 0.2 0.2 0.0 0.3 0.3 PCAT1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 fpkm PCAT1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Liu L, Liu Y, Zhuang C, Xu W, Fu X, et al. (2015). Inducing cell growth arrest and apoptosis by silencing long non-coding RNA PCAT-1 in human bladder cancer. Tumour Biol 36(10): 7685-9. link pubmed
[2]. Shi WH, Wu QQ, Li SQ, Yang TX, Liu ZH, et al. (2015). Upregulation of the long noncoding RNA PCAT-1 correlates with advanced clinical stage and poor prognosis in esophageal squamous carcinoma. Tumour Biol 36(4): 2501-7. link pubmed
[3]. Ge X, Chen Y, Liao X, Liu D, Li F, et al. (2013). Overexpression of long noncoding RNA PCAT-1 is a novel biomarker of poor prognosis in patients with colorectal cancer. Med Oncol 30(2): 588. link pubmed
[4]. Wen J, Xu J, Sun Q, Xing C, Yin W (2016). Upregulation of long non coding RNA PCAT-1 contributes to cell proliferation, migration and apoptosis in hepatocellular carcinoma. Mol Med Rep 13(5): 4481-6. link pubmed
[5]. Zhao B, Hou X, Zhan H (2015). Long non-coding RNA PCAT-1 over-expression promotes proliferation and metastasis in non-small cell lung cancer cells. Int J Clin Exp Med 8(10): 18482-7. link pubmed
[6]. Prensner JR, Chen W, Han S, Iyer MK, Cao Q, et al. (2014). The long non-coding RNA PCAT-1 promotes prostate cancer cell proliferation through cMyc. Neoplasia 16(11): 900-8. link pubmed
[7]. Yan TH, Yang H, Jiang JH, Lu SW, Peng CX, et al. (2015). Prognostic significance of long non-coding RNA PCAT-1 expression in human hepatocellular carcinoma. Int J Clin Exp Pathol 8(4): 4126-31. link pubmed



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