PCAT6

Gene basic information

symbol PCAT6
name prostate cancer associated transcript 6 (non-protein coding)
location 1q32.1
alias_symbol ncRNA-a2|PCAN-R1|KDM5BAS1|onco-lncRNA-96
alias_name prostate cancer-associated noncoding RNA 1
Tissuelung,
Cancerlung cancer,


Description

LncRNA PCAT6 is significantly increased in lung cancer tissues and correlates with metastasis and prognosis of lung cancer patients. PCAT6 significantly promotes cellular proliferation and metastasis, as well as inhibits early apoptosis of lung cancer cells. Molecular analysis reveals that PCAT6 regulates the expression of two pivotal cancer-related proteins, c-Myc and p53, in lung cancer cells. However, PCAT6 is not directly combined with c-Myc and p53 as confirmed by RNA immune-precipitation (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PCAT6 lung lung cancer up onco c-Myc+,p53- + - + - 27458097

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 10 12 14 16 fpkm 0.7 0.9 0.8 1.0 0.4 0.4 0.3 0.0 0.2 1.0 0.3 0.5 1.0 0.4 16.0 1.0 PCAT6

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 5 6 fpkm PCAT6 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wan L, Zhang L, Fan K, Cheng ZX, Sun QC, et al. (2016). Knockdown of Long Noncoding RNA PCAT6 Inhibits Proliferation and Invasion in Lung Cancer Cells. Oncol Res 24(3): 161-70. link pubmed



© Bioinformatics Group of XTBG