PCGEM1

Gene basic information

symbol PCGEM1
name PCGEM1, prostate-specific transcript (non-protein coding)
location 2q32.3
alias_symbol NCRNA00071|LINC00071|PCAT9
alias_name non-protein coding RNA 71|long intergenic non-protein coding RNA 71|prostate cancer associated transcript 9
Tissueprostate,
Cancerprostate cancer,


Description

LncRNA PCGEM1 is up-regulated in prostate cancer and exhibits reciprocal regulation of miR-145. Transfection of the miR-145 expression vector and siRNA PCGEM1 inhibits tumor cell proliferation, migration, and invasion, and induces early apoptosis (1). Moreover, PCGEM1 is regulated by androgen receptor (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PCGEM1 prostate prostate cancer up onco + 14724589
1 PCGEM1 prostate prostate cancer / / SNP 23459097
2 PCGEM1 prostate prostate cancer up onco miR-145- + - + + chemotherapy resistance 25200485
3 PCGEM1 prostate prostate cancer / / hormonal resistance 25744782

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 PCGEM1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 2 4 6 8 10 12 14 fpkm PCGEM1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. He JH, Zhang JZ, Han ZP, Wang L, Lv YB, et al. (2014). Reciprocal regulation of PCGEM1 and miR-145 promote proliferation of LNCaP prostate cancer cells. J Exp Clin Cancer Res 33: 72. link pubmed
[2]. Parolia A, Crea F, Xue H, Wang Y, Mo F, et al. (2015). The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo. Mol Cancer 14: 46. link pubmed



© Bioinformatics Group of XTBG