PCNA-AS1

Gene basic information

symbol PCNA-AS1
name PCNA antisense RNA 1
location 20p12.3
alias_symbol
alias_name
Tissueliver,stomach,
Cancergastric cancer,hepatic cancer,


Description

PCNA-AS1, antisense to PCNA, is increased in gastric cancer tissues and associated with invasion. The expression level of PCNA-AS1 is also related with immunohistochemical biomarkers of BRCA1 (1).
While in hepatocellular carcinoma, PCNA-AS1 is significantly up-regulated in HCC and could promote tumor growth both in vitro and in vivo. The effects of PCNA-AS1 rely on regulation of PCNA via forming RNA hybridization to increase PCNA mRNA stability (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PCNA-AS1 liver hepatic cancer up onco PCNA + 24704293
1 PCNA-AS1 stomach gastric cancer up onco 26731993

External link



Literature

[1]. Dang Y, Wang Y, Ouyang X, Wang L, Huang Q (2015). High Expression of IncRNA-PCNA-AS1 in Human Gastric Cancer and its Clinical Significances. Clin Lab 61(11): 1679-85. link pubmed
[2]. Yuan SX, Tao QF, Wang J, Yang F, Liu L, et al. (2014). Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma. Cancer Lett 349(1): 87-94. link pubmed



© Bioinformatics Group of XTBG