PEG10

Gene basic information

symbol PEG10
name paternally expressed 10
location 7q21.3
alias_symbol KIAA1051|HB-1|MEF3L|RGAG3|Mar2|Mart2|SIRH1|RTL2
alias_name Sushi-Ichi retrotransposon homolog 1|mammalian retrotransposon-derived 2|retrotransposon Gag like 2
Tissuebone marrow,esophagus,
Cancerdiffuse large B cell lymphoma,esophageal cancer,


Description

LncRNA PEG10 is higher in esophageal cancer tissues than in adjacent non-neoplastic tissues. This relatively high expression is significantly associated with the occurrence of lymph node metastases. Moreover, LncRNA PEG10 can promote proliferation and invasion, and inhibit apoptosis (1).
While in diffuse large B cell lymphoma (DLBCL), PEG10 is up-regulated in DLBCL tumorous tissues and cell lines. Moreover, PEG10 is significantly correlated with B symptoms, IPI score, CHOP-like treatment and rituximab. In addition, PEG10 could be a diagnostic marker for distinguishing DLBCL from normal. Besides, knockdown of PEG10 by siRNA could lead to growth arrest and cell apoptosis (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PEG10 esophagus esophageal cancer up onco + - + 25591808
1 PEG10 bone marrow diffuse large B cell lymphoma up onco - - 25864113

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 10 20 30 40 50 fpkm 1.0 2.0 47.0 7.0 12.0 0.5 4.0 0.7 0.5 6.0 3.0 51.0 14.0 0.9 35.0 4.0 PEG10

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Zang W, Wang T, Huang J, Li M, Wang Y, et al. (2015). Long noncoding RNA PEG10 regulates proliferation and invasion of esophageal cancer cells. Cancer Gene Ther 22(3): 138-44. link pubmed
[2]. Peng W, Fan H, Wu G, Wu J, Feng J (2016). Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity. Clin Exp Med 16(2): 177-82. link pubmed



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