|name||paternally expressed 10|
|alias_name||Sushi-Ichi retrotransposon homolog 1|mammalian retrotransposon-derived 2|retrotransposon Gag like 2|
|Cancer||diffuse large B cell lymphoma,esophageal cancer,|
LncRNA PEG10 is higher in esophageal cancer tissues than in adjacent non-neoplastic tissues. This relatively high expression is significantly associated with the occurrence of lymph node metastases. Moreover, LncRNA PEG10 can promote proliferation and invasion, and inhibit apoptosis (1).
While in diffuse large B cell lymphoma (DLBCL), PEG10 is up-regulated in DLBCL tumorous tissues and cell lines. Moreover, PEG10 is significantly correlated with B symptoms, IPI score, CHOP-like treatment and rituximab. In addition, PEG10 could be a diagnostic marker for distinguishing DLBCL from normal. Besides, knockdown of PEG10 by siRNA could lead to growth arrest and cell apoptosis (2).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|1||PEG10||bone marrow||diffuse large B cell lymphoma||up||onco||-||-||25864113|
Expression profile in human body map
. Zang W, Wang T, Huang J, Li M, Wang Y, et al. (2015). Long noncoding RNA PEG10 regulates proliferation and invasion of esophageal cancer cells. Cancer Gene Ther 22(3): 138-44. link pubmed
. Peng W, Fan H, Wu G, Wu J, Feng J (2016). Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity. Clin Exp Med 16(2): 177-82. link pubmed