PICSAR

Gene basic information

symbol PICSAR
name P38 inhibited cutaneous squamous cell carcinoma associated lincRNA
location 21q22.3
alias_symbol PRED74|NLC1-C
alias_name narcolepsy candidate region 1 gene C
Tissueothers,
Cancercutaneous squamous cell carcinoma,


Description

LncRNA PICSAR is up-regulated in cutaneous squamous cell carcinoma (cSCC) cells and is up-regulated by inhibition of p38α and p38δ mitogen-activated protein kinases. Further studies find that PICSAR is specifically expressed by tumor cells in cSCCs but not by keratinocytes in normal skin in vivo. Functionally, knockdown of PICSAR inhibits proliferation and migration of cSCC cells, and suppresses the growth of human cSCC xenografts in vivo. Furthermore, knockdown of PICSAR inhibits extracellular signal-regulated kinase 1/2 activity and up-regulates expression of dual specificity phosphatase 6 (DUSP6) in cSCC cells (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PICSAR others cutaneous squamous cell carcinoma up onco p38 MAPK pathway p-ERK1/2+,Ki-67+ + + 27049681

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.0 3.0 0.0 PICSAR

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Piipponen M, Nissinen L, Farshchian M, Riihilä P, Kivisaari A, et al. (2016). Long Noncoding RNA PICSAR Promotes Growth of Cutaneous Squamous Cell Carcinoma by Regulating ERK1/2 Activity. J Invest Dermatol 136(8): 1701-10. link pubmed



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