|name||P38 inhibited cutaneous squamous cell carcinoma associated lincRNA|
|alias_name||narcolepsy candidate region 1 gene C|
|Cancer||cutaneous squamous cell carcinoma,|
LncRNA PICSAR is up-regulated in cutaneous squamous cell carcinoma (cSCC) cells and is up-regulated by inhibition of p38α and p38δ mitogen-activated protein kinases. Further studies find that PICSAR is specifically expressed by tumor cells in cSCCs but not by keratinocytes in normal skin in vivo. Functionally, knockdown of PICSAR inhibits proliferation and migration of cSCC cells, and suppresses the growth of human cSCC xenografts in vivo. Furthermore, knockdown of PICSAR inhibits extracellular signal-regulated kinase 1/2 activity and up-regulates expression of dual specificity phosphatase 6 (DUSP6) in cSCC cells (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||PICSAR||others||cutaneous squamous cell carcinoma||up||onco||p38 MAPK pathway||p-ERK1/2+,Ki-67+||+||+||27049681|
Expression profile in human body map