PlncRNA-1

Gene basic information

symbol CBR3-AS1
name CBR3 antisense RNA 1
location 21q22.12
alias_symbol PlncRNA-1
alias_name prostate cancer-up-regulated long noncoding RNA 1
Tissueesophagus,liver,prostate,
Canceresophageal squamous cell cancer,hepatic cancer,prostate cancer,


Description

PlncRNA-1 is higher in esophageal squamous carcinoma (1), hepatic carcinoma (2) and prostate cancer (3). Its expression level is associated with prognosis (1). Moreover, it can regulate cancer cell proliferation, invasion, apoptosis and EMT (1, 2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PlncRNA-1 prostate prostate cancer up onco + - hormonal resistance 22264502
1 PlncRNA-1 esophagus esophageal squamous cell cancer up onco + - - 24337686
2 PlncRNA-1 prostate prostate cancer up onco AR,miR-34c and miR-297 + - hormonal resistance 26808578
3 PlncRNA-1 liver hepatic cancer up onco + + + + - 26906068

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.4 1.0 0.6 0.5 0.3 0.4 0.5 0.2 0.1 0.3 0.4 0.5 1.0 0.1 0.4 1.0 PlncRNA-1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm PlncRNA-1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wang CM, Wu QQ, Li SQ, Chen FJ, Tuo L, et al. (2014). Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. Dig Dis Sci 59(3): 591-7. link pubmed
[2]. Dong L, Ni J, Hu W, Yu C, Li H (2016). Upregulation of Long Non-Coding RNA PlncRNA-1 Promotes Metastasis and Induces Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma. Cell Physiol Biochem 38(2): 836-46. link pubmed
[3]. Cui Z, Ren S, Lu J, Wang F, Xu W, et al. (2013). The prostate cancer-up-regulated long noncoding RNA PlncRNA-1 modulates apoptosis and proliferation through reciprocal regulation of androgen receptor. Urol Oncol 31(7): 1117-23. link pubmed



© Bioinformatics Group of XTBG