|name||p53 regulation associated lncRNA|
LncRNA PRAL, on chromosome 17p13.1, whose genomic alterations are significantly associated with reduced survival of hepatic carcinoma (HCC) patients. PRAL could inhibit HCC growth and induce apoptosis through p53. Subsequent investigations indicate that the three stem-loop motif at the 5' end of PRAL facilitates the combination of HSP90 with p53 and thus competitively inhibits MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
Expression profile in human body map