PRAL

Gene basic information

symbol PRAL
name p53 regulation associated lncRNA
location 17p13.1
alias_symbol lncRNA-PRAL
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LncRNA PRAL, on chromosome 17p13.1, whose genomic alterations are significantly associated with reduced survival of hepatic carcinoma (HCC) patients. PRAL could inhibit HCC growth and induce apoptosis through p53. Subsequent investigations indicate that the three stem-loop motif at the 5' end of PRAL facilitates the combination of HSP90 with p53 and thus competitively inhibits MDM2-dependent p53 ubiquitination, resulting in enhanced p53 stability (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PRAL liver hepatic cancer / / HSP90 p53 - + + 26663434

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 fpkm 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.4 0.3 0.0 0.0 0.1 0.0 PRAL

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Zhou CC, Yang F, Yuan SX, Ma JZ, Liu F, et al. (2016). Systemic genome screening identifies the outcome associated focal loss of long noncoding RNA PRAL in hepatocellular carcinoma. Hepatology 63(3): 850-63. link pubmed



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