PTENP1

Gene basic information

symbol PTENP1
name phosphatase and tensin homolog pseudogene 1
location 9p13.3
alias_symbol PTEN2|psiPTEN|PTH2|PTEN-rs|PTENpg1
alias_name
Tissueliver,stomach,
Cancergastric cancer,hepatic cancer,


Description

LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN. PTENP1 and PTEN are down-regulated in several hepatocellular carcinoma (HCC) cells. Elevated level of PTENP1 and PTEN can suppress the oncogenic PI3K/AKT pathway, and inhibit cell proliferation, migration, invasion as well as induce autophagy and apoptosis. Over-expressed PTENP1 decoys oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62. In a word, PTENP1 can inhibit cell proliferation, elicit apoptosis and autophagy, and inhibit angiogenesis (1). Moreover, PTENP1 can act as the diagnosis marker in gastric cancer (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PTENP1 liver hepatic cancer down TS PI3K/AKT pathway miR-17-,miR-19b-,miR-20a- PTEN+,PHLPP(a negative AKT regulator)+,ULK1+,ATG7+,p62+ - + - - - 25617127
1 PTENP1 stomach gastric cancer down / 25694351

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 fpkm 9.0 4.0 3.0 6.0 6.0 1.0 3.0 5.0 0.8 3.0 3.0 4.0 2.0 1.0 6.0 4.0 PTENP1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Chen CL, Tseng YW, Wu JC, Chen GY, Lin KC, et al. (2015). Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. Biomaterials 44: 71-81. link pubmed
[2]. Dong L, Qi P, Xu MD, Ni SJ, Huang D, et al. (2015). Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls. Int J Cancer 137(5): 1128-35. link pubmed



© Bioinformatics Group of XTBG