Gene basic information

symbol PTENP1
name phosphatase and tensin homolog pseudogene 1
location 9p13.3
alias_symbol PTEN2|psiPTEN|PTH2|PTEN-rs|PTENpg1
Cancergastric cancer,hepatic cancer,


LncRNA PTENP1 is a pseudogene of the tumor suppressor gene PTEN. PTENP1 and PTEN are down-regulated in several hepatocellular carcinoma (HCC) cells. Elevated level of PTENP1 and PTEN can suppress the oncogenic PI3K/AKT pathway, and inhibit cell proliferation, migration, invasion as well as induce autophagy and apoptosis. Over-expressed PTENP1 decoys oncomirs miR-17, miR-19b and miR-20a, which would otherwise target PTEN, PHLPP (a negative AKT regulator) and such autophagy genes as ULK1, ATG7 and p62. In a word, PTENP1 can inhibit cell proliferation, elicit apoptosis and autophagy, and inhibit angiogenesis (1). Moreover, PTENP1 can act as the diagnosis marker in gastric cancer (2).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PTENP1 liver hepatic cancer down TS PI3K/AKT pathway miR-17-,miR-19b-,miR-20a- PTEN+,PHLPP(a negative AKT regulator)+,ULK1+,ATG7+,p62+ - + - - - 25617127
1 PTENP1 stomach gastric cancer down / 25694351

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 fpkm 9.0 4.0 3.0 6.0 6.0 1.0 3.0 5.0 0.8 3.0 3.0 4.0 2.0 1.0 6.0 4.0 PTENP1

Expression profile in human body map

Genomic feature visualization


External link


[1]. Chen CL, Tseng YW, Wu JC, Chen GY, Lin KC, et al. (2015). Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. Biomaterials 44: 71-81. link pubmed
[2]. Dong L, Qi P, Xu MD, Ni SJ, Huang D, et al. (2015). Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls. Int J Cancer 137(5): 1128-35. link pubmed

© Bioinformatics Group of XTBG