PVT1

Gene basic information

symbol PVT1
name Pvt1 oncogene (non-protein coding)
location 8q24.21
alias_symbol NCRNA00079|LINC00079|onco-lncRNA-100
alias_name non-protein coding RNA 79|long intergenic non-protein coding RNA 79
Tissuebladder,bone marrow,breast,cervix,colorectum,kidney,liver,lung,ovary,pancreas,pleura,stomach,thyroid,
Canceracute promyelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,gastric cancer,hepatic cancer,malignant pleural mesothelioma,non-small-cell lung cancer,ovarian cancer,pancreatic cancer,renal cancer,thyroid cancer,


Description

LncRNA PVT1 is higher in acute promyelocytic leukemia (APL) (1), malignant pleural mesothelioma (2), non-small cell lung cancer (NSCLC) (3), breast cancer (4), ovarian cancer (5), cervical cancer(6), gastric cancer (7), pancreatic cancer (8), colorectal cancer (9), bladder cancer (10) and renal carcinoma (11). PVT1 expression level is associated with clinicopathological parameters such as lymph node metastasis, TNM stage, prognosis etc. (7, 3). Functionally, PVT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT (6, 3). At molecular level, PVT1 can bind to EZH2 (12). Moreover, PVT1 negatively regulates miR-200b (12), p15, p16 (7), TGF-β1, p-Smad4, Caspase-3 (13), TSHR (14), LATS2 (15) and positively regulate myc (11).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 PVT1 colorectum colorectal cancer up onco + - - 24196785
1 PVT1 breast breast cancer / / SNP 24780616
2 PVT1 pleura malignant pleural mesothelioma up / caspase-3-,C-MYC+ - 24926545
3 PVT1 liver hepatic cancer up onco NOP2+ cell cycle genes + - cancer stem cells 25043274
4 PVT1 stomach gastric cancer up / 25258543
5 PVT1 lung non-small-cell lung cancer up onco + + + - 25400777
6 PVT1 liver hepatic cancer up / - 25624916
7 PVT1 pancreas pancreatic cancer up / - 25668599
8 PVT1 stomach gastric cancer up onco EZH2+ p15- p16- + + - 25890171
9 PVT1 stomach gastric cancer up onco MDR1+,MRP+,mTOR+,HIF-1α+ - chemotherapy resistance 25956062
10 PVT1 ovary ovarian cancer up onco p53-,TIMP1- + chemotherapy resistance 26097562
11 PVT1 thyroid thyroid cancer up onco EZH2 TSHR- + 26427660
12 PVT1 bladder bladder cancer up onco + - chemotherapy resistance 26517688
13 PVT1 bone marrow acute promyelocytic leukemia up onco +MYC + 26545364
14 PVT1 ovary ovarian cancer up onco TGF-β1-,p-Smad4-,caspase-3- - chemotherapy resistance 26884974
15 PVT1 lung non-small-cell lung cancer up onco Mdm2-p53, EZH2 LATS2- + - - 26908628
16 PVT1 stomach gastric cancer up onco - 26925791
17 PVT1 cervix cervical cancer up onco + - + + - chemotherapy resistance 27232880
18 PVT1 cervix cervical cancer up onco EZH2 miR-200b- + + - 27272214
19 PVT1 kidney renal cancer up / MYC+ - CNV 27366943

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 fpkm 0.4 5.0 0.4 0.7 0.6 0.1 0.2 1.0 0.1 0.9 2.0 3.0 2.0 0.5 0.7 1.0 PVT1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm PVT1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zeng C, Yu X, Lai J, Yang L, Chen S, et al. (2015). Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia. J Hematol Oncol 8: 126. link pubmed
[2]. Riquelme E, Suraokar MB, Rodriguez J, Mino B, Lin HY, et al. (2014). Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. J Thorac Oncol 9(7): 998-1007. link pubmed
[3]. Yang YR, Zang SZ, Zhong CL, Li YX, Zhao SS, et al. (2014). Increased expression of the lncRNA PVT1 promotes tumorigenesis in non-small cell lung cancer. Int J Clin Exp Pathol 7(10): 6929-35. link pubmed
[4]. Zhang Z, Zhu Z, Zhang B, Li W, Li X, et al. (2014). Frequent mutation of rs13281615 and its association with PVT1 expression and cell proliferation in breast cancer. J Genet Genomics 41(4): 187-95. link pubmed
[5]. Liu E, Liu Z, Zhou Y (2015). Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1. Int J Clin Exp Pathol 8(4): 3803-10. link pubmed
[6]. Iden M, Fye S, Li K, Chowdhury T, Ramchandran R, et al. (2016). The lncRNA PVT1 Contributes to the Cervical Cancer Phenotype and Associates with Poor Patient Prognosis. PLoS One 11(5): e0156274. link pubmed
[7]. Kong R, Zhang EB, Yin DD, You LH, Xu TP, et al. (2015). Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Mol Cancer 14: 82. link pubmed
[8]. Xie Z, Chen X, Li J, Guo Y, Li H, et al. (2016). Salivary HOTAIR and PVT1 as novel biomarkers for early pancreatic cancer. Oncotarget 7(18): 25408-19. link pubmed
[9]. Takahashi Y, Sawada G, Kurashige J, Uchi R, Matsumura T, et al. (2014). Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. Br J Cancer 110(1): 164-71. link pubmed
[10]. Zhuang C, Li J, Liu Y, Chen M, Yuan J, et al. (2015). Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells. Oncotarget 6(38): 41194-203. link pubmed
[11]. Posa I, Carvalho S, Tavares J, Grosso AR (2016). A pan-cancer analysis of MYC-PVT1 reveals CNV-unmediated deregulation and poor prognosis in renal carcinoma. Oncotarget 7(30): 47033-47041. link pubmed
[12]. Zhang S, Zhang G, Liu J (2016). Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b. APMIS 124(8): 649-58. link pubmed
[13]. Liu E, Liu Z, Zhou Y, Mi R, Wang D (2015). Overexpression of long non-coding RNA PVT1 in ovarian cancer cells promotes cisplatin resistance by regulating apoptotic pathways. Int J Clin Exp Med 8(11): 20565-72. link pubmed
[14]. Zhou Q, Chen J, Feng J, Wang J (2016). Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). Tumour Biol 37(3): 3105-13. link pubmed
[15]. Wan L, Sun M, Liu GJ, Wei CC, Zhang EB, et al. (2016). Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression. Mol Cancer Ther 15(5): 1082-94. link pubmed



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