RGMB-AS1

Gene basic information

symbol RGMB-AS1
name RGMB antisense RNA 1
location 5q15
alias_symbol
alias_name
Tissuelung,
Cancerlung adenocarcinoma,non-small-cell lung cancer,


Description

LncRNA RGMB-AS1 is down-regulated in lung adenocarcinoma, and inhibits cell proliferation, migration and invasion. Further studies show that RGMB-AS1 may down-regulate RGMB expression though interacting with the exon2 sequence of RGMB (1).
However, other study finds that RGMB-AS1 expression is significantly higher in non-small cell lung cancer (NSCLC) tissues and inversely correlated with RGMB mRNA. Both RGMB-AS1 and RGMB expression level are associated with the occurrence of differentiation status, lymph node metastases and TNM stage (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 RGMB-AS1 lung non-small-cell lung cancer up / RGMB- 26055877
1 RGMB-AS1 lung lung adenocarcinoma / onco RGMB+ + + + 26950071

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 fpkm 0.3 0.2 0.2 0.1 0.8 0.1 0.2 0.0 0.0 0.0 0.8 0.1 0.4 0.1 9.0 0.2 RGMB-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 5 fpkm RGMB-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Li P, Zhang G, Li J, Yang R, Chen S, et al. (2016). Long Noncoding RNA RGMB-AS1 Indicates a Poor Prognosis and Modulates Cell Proliferation, Migration and Invasion in Lung Adenocarcinoma. PLoS One 11(3): e0150790. link pubmed
[2]. Li P, Li J, Yang R, Zhang F, Wang H, et al. (2015). Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer. Diagn Pathol 10: 63. link pubmed



© Bioinformatics Group of XTBG