Gene basic information



LncRNA RMEL3 expression is increased in melanoma and subcutaneous tumors compared to primary tumors. RMEL3 expression is also significantly increased in melanomas with a BRAFV600E mutation compared to those with a wild type BRAF or triple wild type for BRAF/RAS/NF1. Reverse phase protein array (RPPA) analysis finds that RMEL3 knockdown reduces cell cycle regulators (like pRB and Cyclin-B1) and anti-apoptotic proteins (like Bcl2), but increases p27 and some pro-apoptotic proteins as the example of caspase-8 and p38 (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 RMEL3 others melanoma up onco MAPK and PI3K signaling + - 27167340


[1]. Goedert L, Pereira CG, Roszik J, Plaça JR, Cardoso C, et al. (2016). RMEL3, a novel BRAFV600E-associated long noncoding RNA, is required for MAPK and PI3K signaling in melanoma. Oncotarget 7(24): 36711-36718. link pubmed

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