| Symbol | RUNXOR |
| Tissue | bone marrow, |
| Cancer | acute myelocytic leukemia, |
LncRNA RUNXOR is transcribed as unspliced transcript from an upstream overlapping promoter. RUNXOR is up-regulated in acute myelocytic leukemia (AML) samples and in response to Ara-C treatment. RUNXOR utilizes its 3'-terminal fragment to directly interact with the RUNX1 promoter and enhancer, and participates in the orchestration of an intra-chromosomal loop. The 3' region of RUNXOR also participates in long-range inter-chromosomal interactions with chromatin regions that are involved in multiple RUNX1 translocations (1).
| LncRNA | tissue | cancer type | expression level | oncogene/suppress gene | pathway | binding gene/factor | associated gene/factor | proliferation | apoptosis | migration | EMT | invasion | metastasis | prognosis | tag | PMID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | RUNXOR | bone marrow | acute myelocytic leukemia | up | / | RUNX1,EZH2 | 24752773 |