SAMMSON

Gene basic information

symbol SAMMSON
name survival associated mitochondrial melanoma specific oncogenic non-coding RNA
location 3p13
alias_symbol
alias_name
Tissueothers,
Cancermelanoma,


Description

LncRNA SAMMSON is up-regulated in melanoma. SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function (1, 2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 SAMMSON others melanoma up onco MITF-,BRAF-,NRAS-,Tp53-,p32 27008969
1 SAMMSON others melanoma / / MITF-,BRAF-,NRAS-,Tp53- 27165740

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.000 0.025 0.050 0.075 0.100 0.125 0.150 0.175 0.200 fpkm 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.1 0.0 0.2 0.1 SAMMSON

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.05 0.10 0.15 0.20 0.25 fpkm SAMMSON type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, et al. (2016). Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531(7595): 518-22. link pubmed
[2]. Goding CR (2016). Targeting the lncRNA SAMMSON Reveals Metabolic Vulnerability in Melanoma. Cancer Cell 29(5): 619-21. link pubmed



© Bioinformatics Group of XTBG