tissues bladder,bone,bone marrow,breast,colorectum,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid
cancer type bladder cancer,breast cancer,colorectal cancer,embryonic carcinoma,esophageal cancer,gallbladder cancer,gastric cancer,glioma,hepatic cancer,laryngeal squamous cell cancer,leukemia,lung cancer,nasopharyngeal cancer,non-small-cell lung cancer,osteosarcoma,ovarian cancer,pancreatic cancer,prostate cancer,renal cancer,thyroid cancer
gene/factor binding to:miR-630,H1.3,let-7,ISM1,miR-141-,c-Myc+,miR-200a,+E2F1,+c-Myc,c-Myc,miR-138,eIF4A3,miR-17-5p- associated with:Snail1-,NANOG+,E-cadherin-,ABCG2,miR-675,Cbl-b-,ZEB2-,Oct4+,+AFB1,MDR,TGF-β1+,p57+,MRP,Twist1-,miR-200s+,p53-,AKT-,ZEB1-,c-Cbl-,cyclin E1+,miR-141-,Bcl-2+,E-Cadherin-,YES1+,RB-,EZH2+,IGF2-,Sox2+,vimentin-,p21-,CDK4+,ANG+,Nkd1- E-cad- β-catenin+,EGFR-,N-Cadherin+,IGF2+,N-cadherin-,TGFBI-,CD133+,cyclin D1+,GSH metabolism,Twist+,+YAP1,Cdc25A-,RUNX1-,ID2+,ZEB1+,c-Myc+,miR675,DNMT1-,IL-6+,cyclin A2+,vimentin+,Bax-,miR-107-,cyclin B1+,miR-148a-3p-
LncRNA H19 is a precursor of miR-675-5p/miR-675-3p. It mainly acts as an oncogene in multiple cancers. It is higher in glioma, thyroid cancer, nasopharyngeal carcinoma, non-small-cell lung cancer, breast cancer, esophageal cancer, gastric cancer, gallbladder carcinoma, pancreatic cancer, colon cancer, bladder cancer, renal cell carcinoma, ovarian cancer, embryonic carcinoma, but has dual roles in hepatocellular carcinoma. H19 expression level is associated with clinicopathological parameters such as tumor differentiation, TNM stage and prognosis etc.. Functionally, H19 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT.. At molecular level, H19 can act as ceRNA via binding to miR-630, miR-17-5p and miR-141. Besides, it can also bind to eIF4A3, ISM1, c-myc and let-7. Mechanistically, H19 negatively regulates RB, P21, Nkd1,, c-Cbl, Cbl-b, EGFR, E-cadherin, miR-107 and miR-141, and positively regulates cyclin A2, cyclin B1, cyclin D1, cyclin E1, CDK4, ID2, YES1, YAP1, EZH2, miR-200s, ZEB1, β-catenin, Twist1, TGF-β1, IL-6 and Vimentin. By regulating these factors, H19 play roles in a variety of biological processes. Besides, H19 affects chemotherapy and hormonotherapy response in multiple cancers. Moreover, polymorphism of H19 may contribute to carcinogenesis.