tissues bone marrow,colorectum
cancer type acute myelocytic leukemia,acute promyelocytic leukemia,colorectal cancer
gene/factor binding to:+PU.1 associated with:
HOTAIRM1 is higher in acute myelocytic leukemia (AML), granulocytic, lower in colorectal cancer. Its expression level is associated with prognosis. It can regulate cancer cell proliferation. Moreover, it is regulated by PU.1.
tissues bladder,bone,bone marrow,breast,cervix,colorectum,endometrium,esophagus,gallbladder,kidney,larynx,liver,lung,nasopharynx,nervous system,others,ovary,pancreas,prostate,stomach,thyroid
cancer type acute myelocytic leukemia,bladder cancer,breast cancer,cervical cancer,colorectal cancer,diffuse large B cell lymphoma,endometrial cancer,epithelial ovarian cancer,esophageal squamous cell cancer,gallbladder cancer,gastric adenocarcinoma,gastric cancer,gastrointestinal stromal tumors,glioma,head and neck squamous cell cancer,hepatic cancer,laryngeal squamous cell cancer,lung adenocarcinoma,lung cancer,melanoma,nasopharyngeal cancer,non-small-cell lung cancer,oral squamous cell cancer,osteosarcoma,ovarian cancer,pancreatic cancer,papillary thyroid cancer,phenotype of urothelial cancer,prostate cancer,renal cancer,sarcoma,small cell lung cancer,triple negative breast cancer
gene/factor binding to:miR-1-,BRD4,miR-326-,miR-1,miR-214-3p,-miR-141-,PRC2,miR-148a,miR-217-,HIF-1α,miR-331-3p,miR-214-,EZH2+,miR-34a,miRNA-130a-,EZH2,IRF1,miR-326,+c-Myc,miR-193a,miR-330-5p,miR-148b-3p-,miR-152-,miR‑373,H3K27me3,LSD1,β-catenin,AGO2,miR-124 associated with:E-cadherin-,SETD2-,NLK-,VEGF+,p53-,Bcl-2+,IGF mRNAs+,HER2-,HOX family,p21-,FGF1+,Slug+,PR+,p-NF-κB+,RBM38-,SUZ12+,pRB-,Col-1+,MMP-9+,caspase-3,SEMA6A-,E2F1+,p16-,MMP2+,MiR-7-,Bcl-2,ZO1-,FOXA1-,NF-κB+,miR34a-,EZH2+,β-catenin+,CDK2+,LAMBC2+,KLF4,+FOXA1,PCBP1-,Twist1+,Twist+,MAPK1+,Ang2+,HOXA5-,P38+,WIF-1-,MTDH+,ZO-1-,NOTCH1+,HES1+,PTEN methylation,caspase-3-,FOXA2-,MMP9+,Bax,MMP1+,STK17B-,ABL2+,pAkt-,p300+,caspase-9-,cyclin D1+,BRCA1-,DNMT3b-,cyclinD1+,DNMT1-,mTOR/p70S6K-,miR-218-,LAMB3+,Snail+,LSH+,HuR+,MMP-2+,+FOXM1,cyclin E+,PIK3R3+,ER+,SNAI1+,Rab22a+,N-cadherin+,CDK4+,p-Akt+,miR-205,CCND1+,PCHD10-,ZEB1+,vimentin+,c-KIT+,Cleaved caspase-3,Cytochrome c,VEGFA+,MMP3+
HOTAIR is a relatively well studied oncogene. It is higher in acute myelocytic leukemia (AML), glioma, laryngeal squamous cell carcinoma, oral squamous carcinoma, nasopharyngeal carcinoma, lung cancer, esophageal squamous cell carcinoma, gastric cancer, hepatocellular carcinoma, gallbladder cancer, pancreatic cancer, colorectal cancer, melanoma, osteosarcoma, bladder cancer, renal carcinoma, ovarian cancer, cervical cancer and endometrial carcinoma. Its expression level is associated with clinicopathological parameters such as lymph node metastasis, tumor size, prognosis. Functionally, HOTAIR regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT. Further studies reveal that HOTAIR modulates physiological factors which participate in cell proliferation, apoptosis, autophagy, EMT, migration, invasion and angiogenesis. Moreover, HOTAIR can bind to miRNAs and modulate their functions, thus affecting cancer progression. Besides, HOTAIR also involves with Chemotherapy and hormone resistance.