SNHG1

Gene basic information

symbol SNHG1
name small nucleolar RNA host gene 1
location 11q12.3
alias_symbol UHG|NCRNA00057|LINC00057|lncRNA16
alias_name U22 snoRNA host gene|non-protein coding RNA 57|long intergenic non-protein coding RNA 57
Tissueliver,nervous system,
Cancerastrocytoma,hepatic cancer,


Description

LncRNA SNHG1 is up-regulated in hepatocellular carcinoma (HCC) tissues (1) and astrocytoma tissues (2). High SNHG1 expression is correlated with large tumor size, poor differentiation, aggressive BCLC stage, and poor prognosis. SNHG1 promotes HCC cells proliferation, cell cycle progression and inhibits HCC cells apoptosis. Further experiments reveal that SNHG1 promotes HCC cells proliferation through inhibiting p53 and p53-target genes expression (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 SNHG1 nervous system astrocytoma up / - 26252651
1 SNHG1 liver hepatic cancer up onco p53-,Bax-,FAS-,CDKNIA- + - - 27133041

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 5 10 15 20 25 fpkm 3.0 25.0 5.0 4.0 5.0 2.0 6.0 5.0 3.0 14.0 25.0 19.0 9.0 1.0 5.0 10.0 SNHG1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 2 4 6 8 10 12 14 fpkm SNHG1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhang M, Wang W, Li T, Yu X, Zhu Y, et al. (2016). Long noncoding RNA SNHG1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis. Biomed Pharmacother 80: 73-9. link pubmed
[2]. Zhi F, Wang Q, Xue L, Shao N, Wang R, et al. (2015). The Use of Three Long Non-Coding RNAs as Potential Prognostic Indicators of Astrocytoma. PLoS One 10(8): e0135242. link pubmed



© Bioinformatics Group of XTBG