| symbol | SNHG12 |
| name | small nucleolar RNA host gene 12 |
| location | 1p35.3 |
| alias_symbol | PNAS-123|LINC00100|ASLNC04080 |
| alias_name | long intergenic non-protein coding RNA 100 |
| Tissue | bone,endometrium, |
| Cancer | endometrial cancer,osteosarcoma, |
SNHG12 is up-regulated in endometrial carcinoma (1) and osteosarcoma tissues and cell lines (2). AMOT mRNA expression level is positively correlated with SNHG12 expression level (2). SNHG12 promotes cell proliferation (1, 2), migration (2) and inhibits apoptosis (1).
| LncRNA | tissue | cancer type | expression level | oncogene/suppress gene | pathway | binding gene/factor | associated gene/factor | proliferation | apoptosis | migration | EMT | invasion | metastasis | prognosis | tag | PMID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | SNHG12 | endometrium | endometrial cancer | up | onco | + | - | 25695231 | |||||||||
| 1 | SNHG12 | bone | osteosarcoma | up | onco | AMOT+ | + | + | 26486328 |
Expression profile in human body map
Expression profile in TCGA
| entrez_id | 85028 |
| ucsc_id | uc057dzf.1 |
| Ensembl_gene_id | ENSG00000197989 |
| HGNC_id | HGNC:30062 |
| Omim_id | |
| cosmic | |
| lncrnadb |
[1]. Zhai W, Li X, Wu S, Zhang Y, Pang H, et al. (2015). Microarray expression profile of lncRNAs and the upregulated ASLNC04080 lncRNA in human endometrial carcinoma. Int J Oncol 46(5): 2125-37. link pubmed
[2]. Ruan W, Wang P, Feng S, Xue Y, Li Y (2016). Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes cell proliferation and migration by upregulating angiomotin gene expression in human osteosarcoma cells. Tumour Biol 37(3): 4065-73. link pubmed