SOCS2-AS1

Gene basic information

symbol SOCS2-AS1
name SOCS2 antisense RNA 1
location 12q22
alias_symbol
alias_name
Tissueprostate,
Cancerprostate cancer,


Description

LncRNA SOCS2-AS1 is higher in castration-resistant prostate cancer model cells, i.e. long-term androgen-deprived (LTAD) cells, than in parental androgen-dependent LNCaP cells. SOCS2-AS1 promotes castration-resistant and androgen-dependent cell growth. Moreover, SOCS2-AS1 knockdown up-regulates genes related to the apoptosis pathway, including tumor necrosis factor superfamily 10 (TNFSF10), and sensitizes prostate cancer cells to docetaxel treatment. Besides, SOCS2-AS1 promotes androgen signaling by modulating the epigenetic control for AR target genes including TNFSF10 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 SOCS2-AS1 prostate prostate cancer up onco 凋亡通路 TNFSF10- + - hormonal resistance 27342777

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 2.00 fpkm 0.7 1.0 0.5 0.4 0.8 0.4 1.0 0.2 0.3 2.0 1.0 0.8 2.0 0.1 2.0 0.6 SOCS2-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 1 2 3 4 5 6 fpkm SOCS2-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Misawa A, Takayama K, Urano T, Inoue S (2016). Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells. J Biol Chem 291(34): 17861-80. link pubmed



© Bioinformatics Group of XTBG