SOX2OT

Gene basic information

symbol SOX2-OT
name SOX2 overlapping transcript
location 3q26.33
alias_symbol DKFZp761J1324|NCRNA00043
alias_name non-protein coding RNA 43
Tissuebreast,colorectum,esophagus,liver,lung,
Cancerbreast cancer,colorectal cancer,esophageal squamous cell cancer,hepatic cancer,lung cancer,


Description

LncRNA SOX2OT is higher in breast cancer (1), lung cancer (2), esophageal squamous cell carcinoma (3), hepatocellular carcinoma (4) and colorectal cancer (5). SOX2OT expression level is negatively correlated with prognosis (4, 2). SOX2OT regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (4, 2). Mechanistically, Sox2ot positively regulates EZH2, Cyclin B1, Cdc2 (2), SOX2 and OCT4 (3).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 SOX2OT esophagus esophageal squamous cell cancer up / SOX2+,OCT4+ mutation,cancer stem cell 24105929
1 SOX2OT lung lung cancer up onco EZH2+,Cyclin B1+,Cdc2+ + - 24927902
2 SOX2OT breast breast cancer up onco SOX2+ + cancer stem cells 25006803
3 SOX2OT liver hepatic cancer up onco + + - 26097588
4 SOX2OT breast breast cancer up / 26409453
5 SOX2OT esophagus esophageal squamous cell cancer / / -miR-211 26862518
6 SOX2OT colorectum colorectal cancer up onco Cyclin B1+,Cdc 25C+,N-cadherin+ + - + + 27353770

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 10 20 30 40 50 60 fpkm 0.1 0.2 62.0 0.1 0.3 0.1 0.1 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.5 0.1 SOX2OT

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.25 0.50 0.75 1.00 1.25 1.50 1.75 fpkm SOX2OT type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Iranpour M, Soudyab M, Geranpayeh L, Mirfakhraie R, Azargashb E, et al. (2016). Expression analysis of four long noncoding RNAs in breast cancer. Tumour Biol 37(3): 2933-40. link pubmed
[2]. Hou Z, Zhao W, Zhou J, Shen L, Zhan P, et al. (2014). A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Int J Biochem Cell Biol 53: 380-8. link pubmed
[3]. Shahryari A, Rafiee MR, Fouani Y, Oliae NA, Samaei NM, et al. (2014). Two novel splice variants of SOX2OT, SOX2OT-S1, and SOX2OT-S2 are coupregulated with SOX2 and OCT4 in esophageal squamous cell carcinoma. Stem Cells 32(1): 126-34. link pubmed
[4]. Shi XM, Teng F (2015). Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis. Int J Clin Exp Pathol 8(4): 4008-14. link pubmed
[5]. Liu S, Xu B, Yan D (2016). Enhanced expression of long non-coding RNA Sox2ot promoted cell proliferation and motility in colorectal cancer. Minerva Med 107(5): 279-86. link pubmed



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