SPRY4-IT1

Gene basic information

symbol SPRY4-IT1
name SPRY4 intronic transcript 1
location 5q31.3
alias_symbol SPRIGHTLY
alias_name
Tissuebladder,breast,colorectum,esophagus,kidney,liver,lung,nervous system,others,stomach,
Cancerbladder cancer,breast cancer,colorectal cancer,esophageal squamous cell cancer,gastric cancer,glioma,hepatic cancer,melanoma,non-small-cell lung cancer,renal clear cell cancer,


Description

LncRNA SPRY4-IT1 is higher in esophageal squamous cell carcinoma (1), glioma (2), melanoma (3), colorectal cancer (4), bladder cancer(5), clear cell renal cell carcinoma (6), lower in non-small cell lung cancer (NSCLC) (7), but has dual roles in gastric cancer (8,9). SPRY4-IT1 expression level is associated with clinicopathological parameters such as tumor stage, histological grade, lymph node metastasis, prognosis etc. (5, 1, 8, 10, 6). Functionally, SPRY4-IT1 regulates cancer cell proliferation, migration, metastasis, invasion, apoptosis and EMT (5, 4, 1, 8, 3, 7, 6). Mechanistically, SPRY4-IT1 negatively regulates E-cadherin (4), ZO-1 (11) and positively regulates N-cadherin, Vimentin (4), Snail, fibronectin (11), cyclin D1, MMP2 and MMP9 (8).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 SPRY4-IT1 others melanoma up onco + - + + 21558391
1 SPRY4-IT1 esophagus esophageal squamous cell cancer up onco + + + - 24810925
2 SPRY4-IT1 lung non-small-cell lung cancer down TS -EZH2 - + - - - - + 24967960
3 SPRY4-IT1 kidney renal clear cell cancer up onco + + + - 25337221
4 SPRY4-IT1 esophagus esophageal squamous cell cancer up / 25608466
5 SPRY4-IT1 breast breast cancer up onco ZNF703+ + - hormonal resistance 25742952
6 SPRY4-IT1 stomach gastric cancer up onco cyclin D1+,MMP2+,MMP9+ + + + - 25835973
7 SPRY4-IT1 bladder bladder cancer up onco + + + - 25973088
8 SPRY4-IT1 stomach gastric cancer down TS - + 26238992
9 SPRY4-IT1 nervous system glioma up onco E-cadherin-,fibronectin+,vimentin+ + + 26464658
10 SPRY4-IT1 others melanoma up onco Ki67+ + - + 26829028
11 SPRY4-IT1 esophagus esophageal squamous cell cancer up onco E-cadherin-,Vimentin+ + + + + 26883252
12 SPRY4-IT1 others melanoma up / - 27239436
13 SPRY4-IT1 esophagus esophageal squamous cell cancer up onco Snail+,E-Cad-,ZO-1-,Vim+,fibronectin+ + + 27250657
14 SPRY4-IT1 liver hepatic cancer up 27278245
15 SPRY4-IT1 colorectum colorectal cancer up onco N-cadherin+,vimentin+,E-cadherin- + - + + 27391336
16 SPRY4-IT1 esophagus esophageal squamous cell cancer up onco ZNF703+ 27453415
17 SPRY4-IT1 nervous system glioma up / - 27460732

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 fpkm 0.4 0.5 0.1 0.4 0.0 0.2 0.2 0.1 0.1 0.3 0.3 0.2 0.2 0.0 0.2 0.4 SPRY4-IT1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Xie HW, Wu QQ, Zhu B, Chen FJ, Ji L, et al. (2014). Long noncoding RNA SPRY4-IT1 is upregulated in esophageal squamous cell carcinoma and associated with poor prognosis. Tumour Biol 35(8): 7743-54. link pubmed
[2]. Liu H, Lv Z, Guo E (2015). Knockdown of long noncoding RNA SPRY4-IT1 suppresses glioma cell proliferation, metastasis and epithelial-mesenchymal transition. Int J Clin Exp Pathol 8(8): 9140-6. link pubmed
[3]. Khaitan D, Dinger ME, Mazar J, Crawford J, Smith MA, et al. (2011). The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. Cancer Res 71(11): 3852-62. link pubmed
[4]. Shen F, Cai WS, Feng Z, Chen JW, Feng JH, et al. (2017). Long non-coding RNA SPRY4-IT1 pormotes colorectal cancer metastasis by regulate epithelial-mesenchymal transition. Oncotarget 8(9): 14479-14486. link pubmed
[5]. Zhao XL, Zhao ZH, Xu WC, Hou JQ, Du XY (2015). Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer. Int J Clin Exp Pathol 8(2): 1954-60. link pubmed
[6]. Zhang HM, Yang FQ, Yan Y, Che JP, Zheng JH (2014). High expression of long non-coding RNA SPRY4-IT1 predicts poor prognosis of clear cell renal cell carcinoma. Int J Clin Exp Pathol 7(9): 5801-9. link pubmed
[7]. Sun M, Liu XH, Lu KH, Nie FQ, Xia R, et al. (2014). EZH2-mediated epigenetic suppression of long noncoding RNA SPRY4-IT1 promotes NSCLC cell proliferation and metastasis by affecting the epithelial-mesenchymal transition. Cell Death Dis 5: e1298. link pubmed
[8]. Peng W, Wu G, Fan H, Wu J, Feng J (2015). Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. Tumour Biol 36(9): 6751-8. link pubmed
[9]. Xie M, Nie FQ, Sun M, Xia R, Liu YW, et al. (2015). Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial-mesenchymal transition. J Transl Med 13: 250. link pubmed
[10]. Zhou Y, Wang DL, Pang Q (2016). Long noncoding RNA SPRY4-IT1 is a prognostic factor for poor overall survival and has an oncogenic role in glioma. Eur Rev Med Pharmacol Sci 20(14): 3035-9. link pubmed
[11]. Zhang CY, Li RK, Qi Y, Li XN, Yang Y, et al. (2016). Upregulation of long noncoding RNA SPRY4-IT1 promotes metastasis of esophageal squamous cell carcinoma via induction of epithelial-mesenchymal transition. Cell Biol Toxicol 32(5): 391-401. link pubmed



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