SRA

Gene basic information

symbol SRA1
name steroid receptor RNA activator 1
location 5q31.3
alias_symbol SRA|STRAA1
alias_name
Tissuebreast,
Cancerbreast cancer,


Description

LncRNA SRA, locates on chromosome 5q31.3 and contains five exons and four introns. It is a non-coding transcript of protein coding gene SRA1. The study evaluates the association between two haplotype tagging SNPs (htSNPs) (rs10463297, rs801460) of the whole LncRNA SRA sequence and breast cancer risk. The results show that rs10463297 TC genotype significantly increases BC risk compared with CC genotype in both the codominant and recessive genetic models. Both TC, TC + CC genotypes of rs10463297 and GA, AA, GA+AA genotypes of rs801460 are significantly associated with estrogen receptor (ER) positivity status. rs10463297 TC, CC and TC + CC genotypes are associated with higher blood plasma SRA mRNA levels compared with the TT genotype (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 SRA breast breast cancer / / SNP 26967566

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 10 12 14 fpkm 7.0 14.0 5.0 7.0 3.0 4.0 7.0 8.0 8.0 7.0 5.0 7.0 6.0 5.0 11.0 9.0 SRA

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Yan R, Wang K, Peng R, Wang S, Cao J, et al. (2016). Genetic variants in lncRNA SRA and risk of breast cancer. Oncotarget 7(16): 22486-96. link pubmed



© Bioinformatics Group of XTBG