T-ALL-R-LncR1

Gene basic information

symbol PAWR
name pro-apoptotic WT1 regulator
location 12q21.2
alias_symbol par-4|PAR4
alias_name prostate apoptosis response-4
Tissuebone marrow,
CancerT acute lymphoblastic leukemia,


Description

LncRNA T-ALL-R-LncR1 is a non-coding transcript of protein coding gene PAWR. LncRNA T-ALL-R-LncR1 is not observed in human normal tissues, while in some tumor tissues indeed. T-ALL-R-LncR1 is markedly expressed in neoplastic T lymphocytes. T-ALL-R-LncR1 knockdown predisposes Jurkat cells to undergo pro-apoptotic factor Par-4-induced apoptosis. Further studies reveal that T-ALL-R-LncR1 knockdown facilitates the formation of a Par-4/THAP1 protein complex, resulting in the activation of caspase-3 and an increase of pro-apoptotic Smac protein in T-ALL cells (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 T-ALL-R-LncR1 bone marrow T acute lymphoblastic leukemia up onco caspase-3+,Smac protein+ - 23906015

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 10 12 fpkm 4.0 7.0 1.0 6.0 5.0 1.0 8.0 0.6 2.0 11.0 5.0 9.0 13.0 0.3 10.0 11.0 T-ALL-R-LncR1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Zhang L, Xu HG, Lu C (2014). A novel long non-coding RNA T-ALL-R-LncR1 knockdown and Par-4 cooperate to induce cellular apoptosis in T-cell acute lymphoblastic leukemia cells. Leuk Lymphoma 55(6): 1373-82. link pubmed



© Bioinformatics Group of XTBG