Gene basic information

symbol TATDN1
name TatD DNase domain containing 1
location 8q24.13
alias_symbol CDA11
Cancernon-small-cell lung cancer,


LncRNA TATDN1 is highly expressed in 95D cells and non-small cell lung cancer (NSCLC) tumor tissues compared to 95C cells. Knockdown of TATDN1-1 by shRNA significantly inhibits cell proliferation, adhesion, migration and invasion in 95D cells. Further mechanism study shows that TATDN1 knockdown suppresses the expression of E-cadherin, HER2, β-catenin and Ezrin. Moreover, knockdown of TATDN1 also inhibits tumor growth and metastasis in a 95D mouse model in vivo by inhibiting β-catenin and Ezrin (1).

Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 TATDN1 lung non-small-cell lung cancer up onco E-cadherin+,HER2+,β-catenin+,Ezrin+ + + + + 26943769

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 6 7 fpkm 2.0 4.0 5.0 4.0 4.0 2.0 3.0 2.0 2.0 3.0 2.0 6.0 6.0 5.0 5.0 7.0 TATDN1

Expression profile in human body map

Genomic feature visualization


External link


[1]. Zequn N, Xuemei Z, Wei L, Zongjuan M, Yujie Z, et al. (2016). The role and potential mechanisms of LncRNA-TATDN1 on metastasis and invasion of non-small cell lung cancer. Oncotarget 7(14): 18219-28. link pubmed

© Bioinformatics Group of XTBG