TCF7

Gene basic information

symbol WSPAR
name WNT signaling pathway activating non-coding RNA
location 5q31.1
alias_symbol TCONS_00009511-XLOC_004555|lncTCF7
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

LncRNA TCF7 that is highly expressed in hepatic carcinoma (HCC) tumors and liver cancer stem cells (CSCs). LncTCF7 is required for liver CSC self-renewal and tumor propagation. Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling (1). Moreover, IL-6 transcriptionally activates the expression of lncTCF7 in HCC cells by activating STAT3, a transcription activator which binds to the promoter region of lncTCF7. Furthermore, knocking-down STAT3 and inhibiting STAT3 activation reduce TCF7 expression. Importantly, RNA interference-based attenuation of TCF7 prevents IL-6-induced EMT and cell invasion (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 TCF7 liver hepatic cancer up onco Wnt signaling. SWI/SNF cancer stem cells 25842979
1 TCF7 liver hepatic cancer / / STAT3 + + + chemotherapy resistance 26452542

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue −0.04 −0.02 0.00 0.02 0.04 fpkm 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TCF7

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.02 0.04 0.06 0.08 0.10 0.12 fpkm TCF7 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wang Y, He L, Du Y, Zhu P, Huang G, et al. (2015). The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell 16(4): 413-25. link pubmed
[2]. Wu J, Zhang J, Shen B, Yin K, Xu J, et al. (2015). Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition. J Exp Clin Cancer Res 34: 116. link pubmed



© Bioinformatics Group of XTBG