THBS4-003

Gene basic information

symbol THBS4
name thrombospondin 4
location 5q14.1
alias_symbol
alias_name
Tissueprostate,
Cancerprostate cancer,


Description

LncRNA-thrombospondin 4 (THBS4)-003 is a processed transcript, which does not encode a protein product. LncRNA THBS4-003 is located at chromosome 5p14.1 and partially overlaps with the protein-coding gene, THBS4. The expression levels of THBS4 and lncRNA-THBS4-003 are significantly higher in prostate cancer (PC) tissues. THBS4 and lncRNA-THBS4-003 significantly promote the migratory and invasive abilities of the PCa cells. Functionally, lncRNA-THBS4-003 and THBS4 regulate levels of MMP-9 through the MAPK signaling pathway (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 THBS4-003 prostate prostate cancer up onco MAPK p38-,MMP‑9-,THBS4+ + + 27357608

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 2.5 5.0 7.5 10.0 12.5 15.0 17.5 20.0 fpkm 6.0 6.0 6.0 21.0 19.0 18.0 0.5 0.1 0.1 1.0 13.0 2.0 3.0 8.0 10.0 8.0 THBS4-003

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Liu J, Cheng G, Yang H, Deng X, Qin C, et al. (2016). Reciprocal regulation of long noncoding RNAs THBS4‑003 and THBS4 control migration and invasion in prostate cancer cell lines. Mol Med Rep 14(2): 1451-8. link pubmed



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