TRPM2-AS is an antisense transcript of TRPM2, which encodes an oxidative stress-activated ion channel, and overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature are found to be linked to poor clinical outcome. Mechanistically, TRPM2-AS knockdown leads to PCa cell apoptosis. Moreover, targets of existing drugs and treatments are found to be consistently associated with high TRPM2-AS levels in both targeted cells and patients, ultimately suggesting that the measurement of expression level of TRPM2-AS allows not only for the early identification of aggressive PCa tumors, but also identifies a subset of at-risk patients who would benefit from currently available, but mostly differently purposed, therapeutic agents (1).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
Expression profile in human body map
Expression profile in TCGA