TRPM2-AS

Gene basic information

SymbolTRPM2-AS
Tissueprostate,
Cancerprostate cancer,


Description

TRPM2-AS is an antisense transcript of TRPM2, which encodes an oxidative stress-activated ion channel, and overexpressed in prostate cancer (PCa). The high expression of TRPM2-AS and its related gene signature are found to be linked to poor clinical outcome. Mechanistically, TRPM2-AS knockdown leads to PCa cell apoptosis. Moreover, targets of existing drugs and treatments are found to be consistently associated with high TRPM2-AS levels in both targeted cells and patients, ultimately suggesting that the measurement of expression level of TRPM2-AS allows not only for the early identification of aggressive PCa tumors, but also identifies a subset of at-risk patients who would benefit from currently available, but mostly differently purposed, therapeutic agents (1).


Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 TRPM2-AS prostate prostate cancer up onco - - 24931166

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 fpkm 0.1 0.2 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 TRPM2-AS

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 fpkm TRPM2-AS type normal tumor

Expression profile in TCGA


Sequence

Literature

[1]. Orfanelli U, Jachetti E, Chiacchiera F, Grioni M, Brambilla P, et al. (2015). Antisense transcription at the TRPM2 locus as a novel prognostic marker and therapeutic target in prostate cancer. Oncogene 34(16): 2094-102. link pubmed



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