UBC1

Gene basic information

symbol BLACAT1
name bladder cancer associated transcript 1 (non-protein coding)
location 1q32.1
alias_symbol linc-UBC1|LINC00912|onco-lncRNA-30
alias_name long intergenic noncoding RNA up-regulated in bladder cancer|long intergenic non-protein coding RNA 912
Tissuebladder,stomach,
Cancerbladder cancer,gastric cancer,


Description

LncRNA UBC1 is significantly up-regulated in gastric cancer tissues (1) and bladder cancer (2). Furthermore, high UBC1 expression is associated with clinicopathological parameter such as lymph-node metastasis, tumor size, TNM stage and poorer prognosis (1, 2). Functionally, UBC1 promotes proliferation, motility and invasion of gastric cancer cells (1, 2). Moreover, UBC1 acts in trans and binds to PRC2 complex and suppresses its target genes in bladder cancer cell (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 UBC1 bladder bladder cancer up onco CCND2+,SERPINB2+,BMP2+,KLF4+ + - 23688781
1 UBC1 stomach gastric cancer up onco + + + - 25755750

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 fpkm 0.0 0.0 0.5 0.1 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.3 0.7 UBC1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Hu Y, Pan J, Wang Y, Li L, Huang Y (2015). Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. Int J Clin Exp Pathol 8(1): 594-600. link pubmed
[2]. He W, Cai Q, Sun F, Zhong G, Wang P, et al. (2013). linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancer. Biochim Biophys Acta 1832(10): 1528-37. link pubmed



© Bioinformatics Group of XTBG