UFC1

Gene basic information

symbol UFC1
name ubiquitin-fold modifier conjugating enzyme 1
location 1q23.3
alias_symbol HSPC155
alias_name
Tissueliver,
Cancerhepatic cancer,


Description

Level of the LncRNA UFC1 is increased in hepatic carcinoma (HCC) tissues compared with controls, and associated with tumor size, barcelona clinic liver cancer stage, and patient outcomes. Transgenic expression of the UFC1 in HCC cells promotes their proliferation and cell-cycle progression and inhibits apoptosis. Moreover, UFC1 interacts directly with the messenger RNA (mRNA) to stabilize protein HuR (encoded by ELAVL1) to increase levels of β-catenin (encoded by CTNNB1) mRNA and protein. However, there is a negative correlation between level of microRNA 34a and UFC1 in HCC tissues; microRNA 34a can reduce the stability of UFC1 (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 UFC1 liver hepatic cancer up onco HuR miR-34a-,β-catenin+ 25449213

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 10 20 30 40 fpkm 24.0 42.0 24.0 27.0 30.0 15.0 28.0 37.0 17.0 34.0 38.0 47.0 42.0 21.0 31.0 31.0 UFC1

Expression profile in human body map

Genomic feature visualization


Sequence

External link



Literature

[1]. Cao C, Sun J, Zhang D, Guo X, Xie L, et al. (2015). The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells. Gastroenterology 148(2): 415-26.e18. link pubmed



© Bioinformatics Group of XTBG