USMycN

Gene basic information

symbol MYCNUT
name MYCN upstream transcript (non-protein coding)
location 2p24.3
alias_symbol lncUSMycN
alias_name
Tissuenervous system,
Cancerneuroblastoma,


Description

LncRNA USMycN is co-amplified with MYCN in 88 of 341 human neuroblastoma tissues. USMycN RNA binds to the RNA-binding protein Nono, leading to N-Myc RNA upregulation and neuroblastoma cell proliferation. High levels of USMycN and NonO expression in human neuroblastoma tissues independently predict poor patient prognoses. Besides, treatment with antisense oligonucleotides targeting USMycN in neuroblastoma-bearing mice statistically significantly hinders tumor progression (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 USMycN nervous system neuroblastoma up onco N-Myc+ + - 24906397

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 fpkm 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 USMycN

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.05 0.10 0.15 0.20 fpkm USMycN type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Liu PY, Erriquez D, Marshall GM, Tee AE, Polly P, et al. (2014). Effects of a novel long noncoding RNA, lncUSMycN, on N-Myc expression and neuroblastoma progression. J Natl Cancer Inst 106(7). link pubmed



© Bioinformatics Group of XTBG