WT1-AS

Gene basic information

symbol WT1-AS
name WT1 antisense RNA
location 11p13
alias_symbol WIT-1|WT1AS|WT1-AS1
alias_name Wilms tumor associated protein
Tissuekidney,liver,stomach,
CancerWilms' tumour,gastric cancer,hepatic cancer,


Description

LncRNA WT1-AS expression is significantly down-regulated in gastric cancer (1), hepatocellular carcinoma (2) and Wilms' tumor (3). It is associated with tumor size and the clinicopathological stage. Functionally, it can inhibit cell proliferation, migration, and invasion. Furthermore, ectopic expression of WT1-AS can inhibit tumor growth and metastasis in vivo. Moreover, WT1-AS could modulate ERK protein phosphorylation and WT1 level (1, 2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 WT1-AS kidney Wilms' tumour down / DNA methylation of the ARR,abnormal splicing epigenetic modification 17210670
1 WT1-AS stomach gastric cancer down TS pERK- - - - - 26449525
2 WT1-AS liver hepatic cancer down TS JAK/STAT3 WT1- - + + chemotherapy resistance 26462627

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 1 2 3 4 5 6 7 fpkm 0.0 0.1 0.0 0.1 0.3 0.3 0.9 0.0 0.0 0.2 0.4 7.0 0.3 0.0 1.0 0.0 WT1-AS

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm WT1-AS type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Du T, Zhang B, Zhang S, Jiang X, Zheng P, et al. (2016). Decreased expression of long non-coding RNA WT1-AS promotes cell proliferation and invasion in gastric cancer. Biochim Biophys Acta 1862(1): 12-9. link pubmed
[2]. Lv L, Chen G, Zhou J, Li J, Gong J (2015). WT1-AS promotes cell apoptosis in hepatocellular carcinoma through down-regulating of WT1. J Exp Clin Cancer Res 34: 119. link pubmed
[3]. Hancock AL, Brown KW, Moorwood K, Moon H, Holmgren C, et al. (2007). A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis. Hum Mol Genet 16(3): 343-54. link pubmed



© Bioinformatics Group of XTBG