XLOC_010588

Gene basic information

symbol TUSC8
name tumor suppressor candidate 8 (non-protein coding)
location 13q14.11
alias_symbol XLOC_010588
alias_name
Tissuecervix,
Cancercervical cancer,


Description

LncRNA XLOC_010588 expression in cervical cancer is significantly down-regulated and correlated with FIGO stage, tumor size and SCC-Ag. Moreover, cervical cancer patients with XLOC_010588 lower expression have shown poorer prognosis. Functionally, ectopic expression of XLOC_010588 inhibits the proliferation of HeLa and SiHa cells. Western blot assays confirm that XLOC_010588 physically associates with c-Myc, consequently decreasing the expression of c-Myc. Besides, the expressions of XLOC_010588 and c-Myc are strongly correlated in cervical cancer tissues (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 XLOC_010588 cervix cervical cancer down TS c-Myc+ - + 24667250

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.0 0.0 0.2 0.9 0.1 0.0 0.1 0.0 1.0 0.0 0.0 0.3 0.4 0.0 0.2 0.0 XLOC_010588

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 fpkm XLOC_010588 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Liao LM, Sun XY, Liu AW, Wu JB, Cheng XL, et al. (2014). Low expression of long noncoding XLOC_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-Myc in cervical cancer. Gynecol Oncol 133(3): 616-23. link pubmed



© Bioinformatics Group of XTBG