|name||ZEB1 antisense RNA 1|
|Cancer||esophageal squamous cell cancer,hepatic cancer,|
LNCRNA ZEB1-AS1 is up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and associated with tumor grade, depth of invasion, lymph node metastasis and prognosis (1).
In hepatic carcinoma, ZEB1-AS1 is frequently up-regulated in hepatocellular carcinoma (HCC) samples, especially in metastatic tumor tissues with its promoter hypomethylation. Aberrant methylation is tightly correlated with overexpression of ZEB1-AS1 in HCC. Patients with ZEB1-AS1 hypomethylation or with high ZEB1-AS1 expression have poor recurrence-free survival. Functionally, ZEB1-AS1 promotes tumor growth and metastasis. Moreover, ZEB1-AS1 gene is located in physical contiguity with ZEB1 and positively regulates the ZEB1 expression (2).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
|0||ZEB1-AS1||liver||hepatic cancer||up||onco||ZEB1+||+||+||+||epigenetic modification||26073087|
|1||ZEB1-AS1||esophagus||esophageal squamous cell cancer||up||/||26617942|
Expression profile in human body map
Expression profile in TCGA
. Wang YL, Bai Y, Yao WJ, Guo L, Wang ZM (2015). Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival. Int J Clin Exp Pathol 8(9): 11871-6. link pubmed
. Li T, Xie J, Shen C, Cheng D, Shi Y, et al. (2016). Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene 35(12): 1575-84. link pubmed