ZEB1-AS1

Gene basic information

symbol ZEB1-AS1
name ZEB1 antisense RNA 1
location 10p11.22
alias_symbol
alias_name
Tissueesophagus,liver,
Canceresophageal squamous cell cancer,hepatic cancer,


Description

LNCRNA ZEB1-AS1 is up-regulated in esophageal squamous cell carcinoma (ESCC) tissues and associated with tumor grade, depth of invasion, lymph node metastasis and prognosis (1).
In hepatic carcinoma, ZEB1-AS1 is frequently up-regulated in hepatocellular carcinoma (HCC) samples, especially in metastatic tumor tissues with its promoter hypomethylation. Aberrant methylation is tightly correlated with overexpression of ZEB1-AS1 in HCC. Patients with ZEB1-AS1 hypomethylation or with high ZEB1-AS1 expression have poor recurrence-free survival. Functionally, ZEB1-AS1 promotes tumor growth and metastasis. Moreover, ZEB1-AS1 gene is located in physical contiguity with ZEB1 and positively regulates the ZEB1 expression (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ZEB1-AS1 liver hepatic cancer up onco ZEB1+ + + + epigenetic modification 26073087
1 ZEB1-AS1 esophagus esophageal squamous cell cancer up / 26617942

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 fpkm 1.0 2.0 0.7 1.0 2.0 0.7 2.0 0.7 0.4 3.0 2.0 3.0 3.0 0.8 2.0 2.0 ZEB1-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 fpkm ZEB1-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wang YL, Bai Y, Yao WJ, Guo L, Wang ZM (2015). Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival. Int J Clin Exp Pathol 8(9): 11871-6. link pubmed
[2]. Li T, Xie J, Shen C, Cheng D, Shi Y, et al. (2016). Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma. Oncogene 35(12): 1575-84. link pubmed



© Bioinformatics Group of XTBG