ZFAS1

Gene basic information

symbol ZFAS1
name ZNFX1 antisense RNA 1
location 20q13.13
alias_symbol HSUP1|HSUP2
alias_name
Tissuecolorectum,liver,stomach,
Cancercolorectal cancer,gastric cancer,hepatic cancer,


Description

LncRNA ZFAS1 is higher in colorectal cancer (1), gastric cancer (2) and hepatocellular carcinoma (3). ZFAS1 expression level is associated with clinicopathological parameters such as lymphatic invasion, TNM stage, prognosis etc. (1, 3). ZFAS1 regulates cancer cell proliferation, migration, metastasis, invasion and apoptosis (1, 3). Mechanistically, ZFAS1 can bind to EZH2, LSD1, CoREST (2), miR-150 (3), miR-590-3p (4). Besides, ZFAS1 negatively regulates PARP (4) and positively regulates ZEB1, MMP14, MMP16 (3), cyclin B1 and p53 (4).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ZFAS1 liver hepatic cancer up onco miR-150 ZEB1+,MMP14+,MMP16+ - - - 26069248
1 ZFAS1 colorectum colorectal cancer up onco miR-590-3p cyclin B1+,p53+,PARP- + 26506418
2 ZFAS1 stomach gastric cancer up onco EZH2, LSD1 and CoREST + - - 27246976
3 ZFAS1 colorectum colorectal cancer up onco + + + - 27461828

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 10 20 30 40 50 fpkm 22.0 32.0 18.0 23.0 21.0 4.0 12.0 42.0 5.0 56.0 48.0 46.0 39.0 8.0 17.0 19.0 ZFAS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0 20 40 60 80 100 120 140 fpkm ZFAS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wang W, Xing C (2016). Upregulation of long noncoding RNA ZFAS1 predicts poor prognosis and prompts invasion and metastasis in colorectal cancer. Pathol Res Pract 212(8): 690-5. link pubmed
[2]. Nie F, Yu X, Huang M, Wang Y, Xie M, et al. (2017). Long noncoding RNA ZFAS1 promotes gastric cancer cells proliferation by epigenetically repressing KLF2 and NKD2 expression. Oncotarget 8(24): 38227-38238. link pubmed
[3]. Li T, Xie J, Shen C, Cheng D, Shi Y, et al. (2015). Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma. Cancer Res 75(15): 3181-91. link pubmed
[4]. Thorenoor N, Faltejskova-Vychytilova P, Hombach S, Mlcochova J, Kretz M, et al. (2016). Long non-coding RNA ZFAS1 interacts with CDK1 and is involved in p53-dependent cell cycle control and apoptosis in colorectal cancer. Oncotarget 7(1): 622-37. link pubmed



© Bioinformatics Group of XTBG