|name||zinc ribbon domain containing 1 antisense, pseudogene|
|Cancer||hepatic cancer,lung cancer,|
The eQTLs SNPs in LncRNA ZNRD1-AS1 may influence both chronic HBV infection and hepatocellular carcinoma (HCC) development. Three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) is tested to investigate ZNRD1-AS1 with the risk of both chronic HBV infection and HCC. The results reveal that variant alleles of all the three SNPs increase host HCC risk, whereas variant allele of rs3757328 is only associated with HBV clearance. Moreover, the haplotype containing variant alleles of the three SNPs are significantly associated with both HCC development and HBV clearance. In-vitro experiments show that ZNRD1 knockdown inhibits the expression of HBV mRNA and promotes proliferation of HepG2.2.15 cells (1).
While in lung cancer, the associations between ZNRD1 eQTLs SNPs in ZNRD1-AS1 and risk of lung cancer in Han Chinese populations is investigated. G allele of SNP rs9261204 is significantly associated with an increased risk of lung cancer when compared with A allele. A weaker, but similar effect is also observed in bladder cancer. SNP rs3757328 is also associated with increased risk of lung cancer (2).
|LncRNA||tissue||cancer type||expression level||oncogene/suppress gene||pathway||binding gene/factor||associated gene/factor||proliferation||apoptosis||migration||EMT||invasion||metastasis||prognosis||tag||PMID|
Expression profile in human body map
Expression profile in TCGA
. Wen J, Liu Y, Liu J, Liu L, Song C, et al. (2015). Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection and hepatocellular carcinoma development. Mol Carcinog 54(11): 1275-82. link pubmed
. Li D, Song L, Wen Z, Li X, Jie J, et al. (2016). Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis- eQTL locus contributing more to the susceptibility of lung cancer. Oncotarget 7(24): 35813-35817. link pubmed