ZNRD1-AS1

Gene basic information

symbol ZNRD1ASP
name zinc ribbon domain containing 1 antisense, pseudogene
location 6p22.1
alias_symbol HTEX4|Em:AB023056.3|HCGVIII|HCGVIII-1
alias_name
Tissueliver,lung,
Cancerhepatic cancer,lung cancer,


Description

The eQTLs SNPs in LncRNA ZNRD1-AS1 may influence both chronic HBV infection and hepatocellular carcinoma (HCC) development. Three ZNRD1 eQTLs SNPs (rs3757328, rs6940552 and, rs9261204) is tested to investigate ZNRD1-AS1 with the risk of both chronic HBV infection and HCC. The results reveal that variant alleles of all the three SNPs increase host HCC risk, whereas variant allele of rs3757328 is only associated with HBV clearance. Moreover, the haplotype containing variant alleles of the three SNPs are significantly associated with both HCC development and HBV clearance. In-vitro experiments show that ZNRD1 knockdown inhibits the expression of HBV mRNA and promotes proliferation of HepG2.2.15 cells (1).
While in lung cancer, the associations between ZNRD1 eQTLs SNPs in ZNRD1-AS1 and risk of lung cancer in Han Chinese populations is investigated. G allele of SNP rs9261204 is significantly associated with an increased risk of lung cancer when compared with A allele. A weaker, but similar effect is also observed in bladder cancer. SNP rs3757328 is also associated with increased risk of lung cancer (2).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ZNRD1-AS1 liver hepatic cancer / / + SNP 25110835
1 ZNRD1-AS1 lung lung cancer up onco ZNRD1 SNP 27166266

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm 0.2 0.4 0.4 0.3 0.2 0.2 0.4 0.3 0.1 0.2 0.8 0.7 0.5 0.1 1.0 0.5 ZNRD1-AS1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.2 0.4 0.6 0.8 1.0 fpkm ZNRD1-AS1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Wen J, Liu Y, Liu J, Liu L, Song C, et al. (2015). Expression quantitative trait loci in long non-coding RNA ZNRD1-AS1 influence both HBV infection and hepatocellular carcinoma development. Mol Carcinog 54(11): 1275-82. link pubmed
[2]. Li D, Song L, Wen Z, Li X, Jie J, et al. (2016). Strong evidence for LncRNA ZNRD1-AS1, and its functional Cis- eQTL locus contributing more to the susceptibility of lung cancer. Oncotarget 7(24): 35813-35817. link pubmed



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