ZXF1

Gene basic information

symbol ACTA2-AS1
name ACTA2 antisense RNA 1
location 10q23.31
alias_symbol uc001kfo.1|ZXF1
alias_name
Tissuelung,
Cancerlung adenocarcinoma,


Description

LncRNA ZXF1 level is remarkably increased in lung adenocarcinoma tissues compared with adjacent non-cancerous lung tissues, and up-regulated ZXF1 is correlated with lymph node metastasis, tumor pathological stage and the extent of lymph node metastasis. The 3-year overall survival rate of patients with higher ZXF1 levels is remarkably reduced compared with patients with lower ZXF1 levels. Inhibition of ZXF1 by siRNA decreases the migration and invasion of A549 cells in vitro, while there is no significant effect in cell proliferation (1).


Cancer related information

download as excel csv txt

LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ZXF1 lung lung adenocarcinoma up onco + + - 24721325

Expression profile

adipose adrenal brain breast colon heart kidney leukocyte liver lung lymph node ovary prostate skeletal muscle testis thyroid tissue 0 2 4 6 8 10 12 fpkm 0.7 8.0 0.5 4.0 1.0 0.2 0.7 0.1 0.0 0.7 1.0 3.0 13.0 0.1 2.0 0.5 ZXF1

Expression profile in human body map

TCGA-BLCA TCGA-BRCA TCGA-CESC TCGA-HNSC TCGA-KICH TCGA-KIRC TCGA-KIRP TCGA-LIHC TCGA-LUAD TCGA-LUSC TCGA-PRAD TCGA-STAD TCGA-THCA TCGA-UCEC tissue 0.0 0.5 1.0 1.5 2.0 2.5 3.0 3.5 4.0 fpkm ZXF1 type normal tumor

Expression profile in TCGA


Genomic feature visualization


Sequence

External link



Literature

[1]. Zhang L, Zhou XF, Pan GF, Zhao JP (2014). Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma. Biomed Pharmacother 68(4): 401-7. link pubmed



© Bioinformatics Group of XTBG