ZXF2

Gene basic information

SymbolZXF2
Tissuelung,
Cancerlung adenocarcinoma,


Description

LncRNA ZXF2 is higher in lung adenocarcinoma specimens and correlated with tumor lymph node metastasis and poor prognosis of the patients. Functionally, siRNA-ZXF2 treatment inhibits cell proliferation, leading to cell cycle arrest. The cell migration and invasion are suppressed by siRNA-ZXF2 treatment. Further biochemical studies reveal that the knockdown of ZXF2 leads to down-regulation of c-Myc signaling (1).


Cancer related information

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LncRNA tissue cancer type expression level oncogene/suppress gene pathway binding gene/factor associated gene/factor proliferation apoptosis migration EMT invasion metastasis prognosis tag PMID
0 ZXF2 lung lung adenocarcinoma up onco c-Myc signaling + + + 25896422

Literature

[1]. Yang ZT, Li Z, Wang XG, Tan T, Yi F, et al. (2015). Overexpression of Long Non-Coding RNA ZXF2 Promotes Lung Adenocarcinoma Progression Through c-Myc Pathway. Cell Physiol Biochem 35(6): 2360-70. link pubmed



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